The emergence of variants of the SARS-CoV-2 virus poses challenges to the effectiveness of currently available vaccines and therapeutic antibodies. The research group led by Professor Bai Chen has analyzed the impact of mutations on the binding affinity between the spike protein of the novel coronavirus and neutralizing antibodies, antibodies from recovered patients, and artificially designed antibody mimetics by calculating changes in binding free energy. The study evaluates the differences between target sites on the spike protein for several antibodies. The results provided in this paper ma

The Bai Chen Research Group Publishes Paper in the Biology Journal: "Explaining the Structure-Function Relationship of Three Types of G-Protein-Coupled Receptors from an Energetic Perspective"

"In recent years, traditional drug design has required extensive research time and development costs. Computational methods have been widely used to enhance the efficacy and effectiveness of drug discovery and pipelines, leading to the approval of numerous new drugs. The White Morning Research Group published a review article in the International Journal of Molecular Sciences, focusing on the application and challenges of computational methods in assisting drug target identification, lead compound discovery, and optimization."