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Academic Achievements

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    2024.09.18
    JACS | Bai Chen's team from MoMed Biotech reveals the activation mechanism of the important chloride ion channel protein glycine receptor in the nervous system through computational simulation.

    In September 2024, Bai Chen's team from MoMed Biotech published a research paper titled "Exploring the Activation Process of the Glycine Receptor" online in the journal JACS. This study not only helps us deeply understand the activation mechanism of the glycine receptor (GlyR), a potential therapeutic target for alleviating chronic pain, predicts and validates important mutation sites, but also opens up a new way for developing more effective treatment regimens.

    2024.05.14
    PNAS | The Bai Chen team and collaborators revealed the activation mechanism of mGlu2 in the C class GPCR family and important mutation sites through computational simulations.

    2024.05.13
    Angew. Chem. Int. Ed. | Wu Dongdong/Bai Chen team explores ultra-thin peptide-based nanosheets.

    In May 2024, Professor Wu Dongdong from the Biomedical Engineering College at Sichuan University and the MoMed Biotech team led by Bai Chen published a research paper titled "Multi-Responsive Peptide-Based Ultrathin Nanosheets Prepared by a Horizontal Monolayer Assembly" in Angew. Chem. Int. Ed. This work not only sets a new thickness record for peptide-based nanomaterials but also provides new ideas for functionalizing and intelligentizing 2D materials.

    2024.05.06
    Brief Bioinform" | Wu Song/Bai Chen team jointly develops molecular generation model InterDiff.

    Recently, MoMed Biotech, in collaboration with Professor Wu Song's team from Shenzhen University, has developed a molecular generation model called InterDiff based on hotspots residues and interaction cues. This research was published in the top journal in the field of bioinformatics, Briefings in Bioinformatics. InterDiff utilizes a diffusion model as its core architecture and employs the technique of cue learning to guide the generation process of molecules, specifically targeting interactions with protein pocket residues.

    2024.02.07
    JACS | The Bai Chen team and collaborators reveal the activation mechanism and important mutation sites of the ion channel TMEM16A through computational simulations.

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